BACKAn Osteoinductive Hybrid Prosthesis
[Licensing negotiation in progress]
[Invitation for Expression of Interest- Deadline: 17 January 2022]
We are inviting expressions of interest (EoI) for commercializing “An Osteoinductive Hybrid Prosthesis” technology. The innovation is developed by Professor QIN Ling, Department of Orthopaedics & Traumatology of The Chinese University of Hong Kong (CUHK Reference: 18/MED/820).
The Technology
This invention primarily focuses on dental applications. Prosthetic dentistry involves the restoration of missing or deficient teeth with the use of artificial components. Such artificial components typically include a dental implant and an abutment, a prosthetic tooth or bridge or arch that is secured to the dental implant.
A dental implant (also known as endosseous implant or fixture) is a surgical component that is inserted to the jaw bones to support a dental prosthesis such as a crown, bridge, denture, facial prosthesis or to act as an orthodontic anchor. The implant fixture is first placed and a variable amount of healing time is required for osseointegration before attaching the abutment and dental prosthetic to the implant. Osseointegration is the biologic process where bone fuses tightly to the surface of specific materials such as titanium or ceramics.
Magnesium (Mg), which is an important ‘co-enzyme’ participating in over 300 biochemical reactions in human body and accounts for about 30 grams in an adult and has been reported to promote new bone formation during its degradation via extensive in vitro and in vivo studies (Zhang, Xu et al. 2016, Zhao, Witte et al. 2017).
The combined use of traditional devices and Mg materials may be a feasible method to push forward the translational research of Mg-containing implants to clinical applications (Zhang, Xu et al. 2016).
A hybrid system is developed to incorporate Mg into the dental implant design for facilitating the healing process of bone tissue around prosthesis so as to enhance the stability of the implantation.
This invention is proposed to use conventional permanent prosthesis, such as dental implant to support and anchor the dental prosthesis to the jaw bones of patient. The implant is hollow and hence it can house a component said rod, which is made of biodegradable materials. For the healing enhancement effect, numerous perforations or holes are created on the wall of the implant allowing the release of agents from the rod that shorten the bone-to-implant integration time, promoting new bone formation and nerve regeneration.
Commercialization
The technology is now available for licensing on an exclusive basis. In order to fully realize the benefit of the technology, we expect substantial investment is necessary to enable further research and development. In addition to the financial commitment, the licensee is expected to have the appropriate expertise as well as plans in marketing and strategizing the end product to ensure successful transfer of the technology to the society. Previous or existing business involvement and experience in this area is a plus.
This invitation of expression of interest is without prejudice. We also stress that this invitation is not a tender, and the University is not bound to accept any offer, or to accept the highest monetary offer, as there are additional considerations (such as the widest possible benefit to the community) that we, as a public institution, will need to take into consideration.
An Osteoinductive Hybrid Prosthesis
[Licensing negotiation in progress]
[Invitation for Expression of Interest- Deadline: 17 January 2022]
We are inviting expressions of interest (EoI) for commercializing “An Osteoinductive Hybrid Prosthesis” technology. The innovation is developed by Professor QIN Ling, Department of Orthopaedics & Traumatology of The Chinese University of Hong Kong (CUHK Reference: 18/MED/820).
The Technology
This invention primarily focuses on dental applications. Prosthetic dentistry involves the restoration of missing or deficient teeth with the use of artificial components. Such artificial components typically include a dental implant and an abutment, a prosthetic tooth or bridge or arch that is secured to the dental implant.
A dental implant (also known as endosseous implant or fixture) is a surgical component that is inserted to the jaw bones to support a dental prosthesis such as a crown, bridge, denture, facial prosthesis or to act as an orthodontic anchor. The implant fixture is first placed and a variable amount of healing time is required for osseointegration before attaching the abutment and dental prosthetic to the implant. Osseointegration is the biologic process where bone fuses tightly to the surface of specific materials such as titanium or ceramics.
Magnesium (Mg), which is an important ‘co-enzyme’ participating in over 300 biochemical reactions in human body and accounts for about 30 grams in an adult and has been reported to promote new bone formation during its degradation via extensive in vitro and in vivo studies (Zhang, Xu et al. 2016, Zhao, Witte et al. 2017).
The combined use of traditional devices and Mg materials may be a feasible method to push forward the translational research of Mg-containing implants to clinical applications (Zhang, Xu et al. 2016).
A hybrid system is developed to incorporate Mg into the dental implant design for facilitating the healing process of bone tissue around prosthesis so as to enhance the stability of the implantation.
This invention is proposed to use conventional permanent prosthesis, such as dental implant to support and anchor the dental prosthesis to the jaw bones of patient. The implant is hollow and hence it can house a component said rod, which is made of biodegradable materials. For the healing enhancement effect, numerous perforations or holes are created on the wall of the implant allowing the release of agents from the rod that shorten the bone-to-implant integration time, promoting new bone formation and nerve regeneration.
Commercialization
The technology is now available for licensing on an exclusive basis. In order to fully realize the benefit of the technology, we expect substantial investment is necessary to enable further research and development. In addition to the financial commitment, the licensee is expected to have the appropriate expertise as well as plans in marketing and strategizing the end product to ensure successful transfer of the technology to the society. Previous or existing business involvement and experience in this area is a plus.
This invitation of expression of interest is without prejudice. We also stress that this invitation is not a tender, and the University is not bound to accept any offer, or to accept the highest monetary offer, as there are additional considerations (such as the widest possible benefit to the community) that we, as a public institution, will need to take into consideration.
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Esther Tang
Office of Research and Knowledge Transfer Services
QIN Ling
CHAU Wing Ho
WANG Jiali
XU Jiankun
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