BACKA Novel Bioactive and Degradable Magnesium-based Screw Construct for Fracture Fixation
[Licensing negotiation in progress]
[Invitation for Expression of Interest- Deadline: 17 January 2022]
We are inviting expressions of interest (EoI) for commercializing “A Novel Bioactive and Degradable Magnesium-based Screw Construct for Fracture Fixation” technology. The innovation is developed by Professor QIN Ling, of Orthopaedics and Traumatology of The Chinese University of Hong Kong (CUHK Reference: 13/MED/528).
The Technology
Trauma-induced or osteoporotic fracture is common. Delay in fracture healing or non-union is current challenges in our orthopaedic clinics. Rigid fixation of fractured bone is challenging as the current metal implants used is made of stainless steel or titanium (Ti) that have much higher Young's modulus than natural bones. This induces stress shielding effects to the fractured bone and accelerates bone loss. Our recent research in medical biodegradable magnesium (Mg) can overcome the limitation of rigid fixation because of similar mechanical properties of Mg compared to the bone. We are able to prove the enhancement of fracture healing caused by Mg implants. However, Mg alone can't provide enough mechanical support as it degrades with healing over time. Therefore, we have the construct to coat the biodegradable Mg with a thin layer of polymer coating film and then combine it with the currently clinical locked plate system made of titanium for fracture fixation. Our invention develops a novel biological fixation system and are highly desirable for fracture repair. The Mg in the system will contribute greatly to promote the fracture healing and provide proper support to avoid stress shielding effect. While, the Ti in the system will become the mechanical support providing part and hold the whole fixation structure. To summarize, our invention will improve, and may even replace current Ti -fixation system in fracture fixation, especially for the osteoporotic fracture.
Commercialization
The technology is now available for licensing on an exclusive basis. In order to fully realize the benefit of the technology, we expect substantial investment is necessary to enable further research and development. In addition to the financial commitment, the licensee is expected to have the appropriate expertise as well as plans in marketing and strategizing the end product to ensure successful transfer of the technology to the society. Previous or existing business involvement and experience in this area is a plus.
This invitation of expression of interest is without prejudice. We also stress that this invitation is not a tender, and the University is not bound to accept any offer, or to accept the highest monetary offer, as there are additional considerations (such as the widest possible benefit to the community) that we, as a public institution, will need to take into consideration.
A Novel Bioactive and Degradable Magnesium-based Screw Construct for Fracture Fixation
[Licensing negotiation in progress]
[Invitation for Expression of Interest- Deadline: 17 January 2022]
We are inviting expressions of interest (EoI) for commercializing “A Novel Bioactive and Degradable Magnesium-based Screw Construct for Fracture Fixation” technology. The innovation is developed by Professor QIN Ling, of Orthopaedics and Traumatology of The Chinese University of Hong Kong (CUHK Reference: 13/MED/528).
The Technology
Trauma-induced or osteoporotic fracture is common. Delay in fracture healing or non-union is current challenges in our orthopaedic clinics. Rigid fixation of fractured bone is challenging as the current metal implants used is made of stainless steel or titanium (Ti) that have much higher Young's modulus than natural bones. This induces stress shielding effects to the fractured bone and accelerates bone loss. Our recent research in medical biodegradable magnesium (Mg) can overcome the limitation of rigid fixation because of similar mechanical properties of Mg compared to the bone. We are able to prove the enhancement of fracture healing caused by Mg implants. However, Mg alone can't provide enough mechanical support as it degrades with healing over time. Therefore, we have the construct to coat the biodegradable Mg with a thin layer of polymer coating film and then combine it with the currently clinical locked plate system made of titanium for fracture fixation. Our invention develops a novel biological fixation system and are highly desirable for fracture repair. The Mg in the system will contribute greatly to promote the fracture healing and provide proper support to avoid stress shielding effect. While, the Ti in the system will become the mechanical support providing part and hold the whole fixation structure. To summarize, our invention will improve, and may even replace current Ti -fixation system in fracture fixation, especially for the osteoporotic fracture.
Commercialization
The technology is now available for licensing on an exclusive basis. In order to fully realize the benefit of the technology, we expect substantial investment is necessary to enable further research and development. In addition to the financial commitment, the licensee is expected to have the appropriate expertise as well as plans in marketing and strategizing the end product to ensure successful transfer of the technology to the society. Previous or existing business involvement and experience in this area is a plus.
This invitation of expression of interest is without prejudice. We also stress that this invitation is not a tender, and the University is not bound to accept any offer, or to accept the highest monetary offer, as there are additional considerations (such as the widest possible benefit to the community) that we, as a public institution, will need to take into consideration.
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Esther Tang
Office of Research and Knowledge Transfer Services
QIN Ling
TIAN Li
NGAI To
WU Chi
LEUNG Kwok Sui
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