BACKAn non-destructive antigen retrieval method with mild conditions for 3D histology
[Licensing negotiation in progress]
[Invitation for Expression of Interest- Deadline: 22 May 2025]
We are inviting expressions of interest (EoI) for commercializing “An non-destructive antigen retrieval method with mild conditions for 3D histology” technology. The innovation is developed by Professor LAI Hei Ming, Professor of Department of Chemical Pathology of The Chinese University of Hong Kong (CUHK Reference: 25/MED/1493).
The Technology
Antigen retrieval is the cornerstone for modern section-based immunohistochemistry, especially for paraffin sections. However, it typically employs harsh treatment conditions, including prolonged treatment at temperatures >80C, and is inapplicable to tissue volumes for 3D histology. Tissue volumes in particular requires different antigen retrieval methods, where the direct extrapolation of 2D antigen retrieval methods is inapplicable or not useful.
This invention disclose a chemical cocktail that when tissue volumes are incubated in, efficiently achieves antigen retrieval throughout the whole tissue volume for subsequent 3D histology, including deeply penetrating immunohistochemistry and lectin histochemistry that is otherwise impossible. It does not require high temperature treatment and hence tissues are particularly stable.
Commercialization
The technology is now available for licensing on an exclusive basis. In order to fully realize the benefit of the technology, we expect substantial investment is necessary to enable further research and development. In addition to the financial commitment, the licensee is expected to have the appropriate expertise as well as plans in marketing and strategizing the end product to ensure successful transfer of the technology to the society. Previous or existing business involvement and experience in this area is a plus.
This invitation of expression of interest is without prejudice. We also stress that this invitation is not a tender, and the University is not bound to accept any offer, or to accept the highest monetary offer, as there are additional considerations (such as the widest possible benefit to the community) that we, as a public institution, will need to take into consideration.
An non-destructive antigen retrieval method with mild conditions for 3D histology
[Licensing negotiation in progress]
[Invitation for Expression of Interest- Deadline: 22 May 2025]
We are inviting expressions of interest (EoI) for commercializing “An non-destructive antigen retrieval method with mild conditions for 3D histology” technology. The innovation is developed by Professor LAI Hei Ming, Professor of Department of Chemical Pathology of The Chinese University of Hong Kong (CUHK Reference: 25/MED/1493).
The Technology
Antigen retrieval is the cornerstone for modern section-based immunohistochemistry, especially for paraffin sections. However, it typically employs harsh treatment conditions, including prolonged treatment at temperatures >80C, and is inapplicable to tissue volumes for 3D histology. Tissue volumes in particular requires different antigen retrieval methods, where the direct extrapolation of 2D antigen retrieval methods is inapplicable or not useful.
This invention disclose a chemical cocktail that when tissue volumes are incubated in, efficiently achieves antigen retrieval throughout the whole tissue volume for subsequent 3D histology, including deeply penetrating immunohistochemistry and lectin histochemistry that is otherwise impossible. It does not require high temperature treatment and hence tissues are particularly stable.
Commercialization
The technology is now available for licensing on an exclusive basis. In order to fully realize the benefit of the technology, we expect substantial investment is necessary to enable further research and development. In addition to the financial commitment, the licensee is expected to have the appropriate expertise as well as plans in marketing and strategizing the end product to ensure successful transfer of the technology to the society. Previous or existing business involvement and experience in this area is a plus.
This invitation of expression of interest is without prejudice. We also stress that this invitation is not a tender, and the University is not bound to accept any offer, or to accept the highest monetary offer, as there are additional considerations (such as the widest possible benefit to the community) that we, as a public institution, will need to take into consideration.